"Many studies have demonstrated that psychological stress, through its suppression of both innate and adaptive immune responses, may be an important factor in the ability to control infections. Occasionally, studies find a weak or no association between a particular type of infection and a particular stressor. Various forms of Herpes infections have demonstrated such inconsistencies. Other studies have shown that the severity of a particular stressor is not as impactful on infection vulnerability as the chronicity of the exposure or the adaptability of the individual."
Ashcraft, K. A., et al. (2008). Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses. Brain Behav Immun. Nov; 22(8): 1231–1240. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721735/O
Harpaz R., et al. (2014). Psychological Stress as a Trigger for Herpes Zoster: Might the Conventional Wisdom Be Wrong? Clinical Infectious Diseases, Volume 60, Issue 5, 1 March 2015, Pages 781–785, https://doi.org/10.1093/cid/ciu889
Mortimer, Jane & Sephton, Sandra & Kimerling, Rachel & Butler, Lisa & Bernstein, Aaron & Spiegel, David. (2005). Chronic stress, depression and immunity in spouses of metastatic breast cancer patients. Clinical Psychologist. 9. 59 - 63.
Image credit: "File:Primary immune response 1.png" by me=Sciencia58 an the makers of the single images Domdomegg, [1], Fæ, Petr94, Manu5 is licensed under CC BY-SA 4.0
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